Congress abstract
Remzi M, Tinzl M, Marberger M
- This abstract was presented as a poster at the World Congress of Controversies in Urology (CURy) meeting, 31 January -3 February 2008, Barcelona, Spain.
- The study aimed to determine the diagnostic utility of the PCA3 Assay in 65 men with 1 or 2 negative prostate biopsies who were scheduled for repeat biopsy at the Medical University of Vienna and was part of a prospective, multi-national, multi-centre, European study1.
- It showed that in men with a serum PSA of 2.5-10 ng/mL, at a PCA3 Score cut-off of 35, the specificity is 74%, the negative predictive value 82% and 33% of repeat biopsies could be avoided.
- Follow-up of men with a PCA3 Score > 35 and a negative repeat biopsy showed that 60% of these men has high-grade prostate intraepithelial neoplasia (HGPIN; Table).
- Preliminary data show that the majority of these men has a positive biopsy at further follow-up.
eristics of men with PCA3 Score > 35 and negative repeat biopsy
| Total PSA | No. prior biopsies | PCA3 Score | Biopsy result | HGPIN | Follow-up biopsy result | no. positive cores | Serum PSA | Gleason score | Radical prostatectomy | Stage | Post radical prostatectomy Gleason |
| 8.2 | 1 | 40 | n | ||||||||
| 5.8 | 2 | 46 | n | ||||||||
| 2.6 | 1 | 46 | n | ||||||||
| 7.2 | 1 | 47 | n | y | p | 4/10 | 6.1 | 6 (3+3) | jan/07 | pT2a, N0 | 6 (3+3) |
| 6.3 | 1 | 47 | n | y | |||||||
| 3.9 | 1 | 50 | n | ||||||||
| 4.7 | 1 | 52 | n | y | |||||||
| 8.4 | 1 | 64 | n | y | 8.7 | ||||||
| 3.1 | 1 | 184 | n | y | n | 0/14 | 2.7 | ||||
| 6.7 | 2 | 192 | n | y | p | 2/10 | 12 | 7 (4+3) | nd | nd | nd |
1) Haese A, et al. Eur Urol. 2008 Nov;54:1081-8
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