PCA3 Materials & News

Deras IL, Aubin SMJ, Blase A, Day JR, Koo S, Partin AW, Ellis WJ, Marks LS, Fradet Y, Rittenhouse H, Groskopf J. J Urol 2008;179:1587-92

• This study in 570 men scheduled for prostate biopsy demonstrates that the Prostate CAncer gene 3 (PCA3) Assay can aid in guiding decision which men need a prostate biopsy.
• The probability of a positive prostate biopsy increased continuously as the PCA3 Score increased.
• The mean and median PCA3 Scores were higher in men with (or suspicious of) prostate cancer (PCa) than in men with no pathology or inflammation (Figure).
• The diagnostic accuracy of the PCA3 Assay was statistically significantly greater than that of serum prostate specific antigen (PSA; Table).
• The PCA3 Score was, unlike serum PSA level, independent of prostate volume.
• The PCA3 Score was also independent of serum PSA level and whether the subject had his first (N=277) or a repeat (N=280) biopsy (Table).
• Logistic regression analysis showed that the PCA3 Score can be combined with other factors, such as prostate volume, digital rectal examination (DRE) outcome and serum PSA level, into a nomogram to improve the prediction of the outcome of a biopsy (Table).

AUC ROC: Area Under the Receiver Operating Characteristic Curve

More information: Article at PubMed