Publication
Marks LS, Fradet Y, Deras IL, Blase A, Mathis J, Aubin SMJ, Cancio AT, Desaulniers M, Ellis WJ, Rittenhouse H, Groskopf J. Urology 2007;69:532-5
- This study in 233 men with ≥ 1 negative biopsy demonstrates the clinical utility of the PCA3 Score in guiding decision which men need repeat biopsy.
- In total, 27% of men had a positive repeat biopsy.
- The repeat biopsy rate increased with higher PCA3 Scores (Figure).
- A PCA3 Score of 35 provided the greatest diagnostic accuracy, i.e. balance between sensitivity (58%) and specificity (72%).
- Men with a PCA3 Score < 35 had a decreased likelihood of a positive biopsy (17%); men with a PCA3 Score ≥ 35 a 2.5-fold increased likelihood (43%).
More information: Article at PubMed