Publication
Vlaeminck-Guillem V, Bandel M, Cottancin M, Rodriguez-Lafrasse C, Bohbot J-M, Sednaoui P. Prostate 2011; doi: 10.1002/pros.21457
- This single-centre study in 34 patients with chronic prostatitis shows that the PCA3 Score is not affected by cytologically or bacteriologically diagnosed chronic prostatitis. The PCA3 test is a valuable tool in patients with elevated PSA levels and suspicion of chronic prostatitis to select those patients who will really benefit from prostate biopsy from those in whom a biopsy can be avoided
- This single-centre study included 34 evaluable patients with chronic prostatitis as diagnosed with the Meares-Stamey four-glass localization test. The urine sample collected after prostate massage for the Meares-Stamey localization test was also used for the PCA3 test
- The mean and median PCA3 Scores were low and comparable in men with bacterial chronic prostatitis, abacterial chronic prostatitis and prostatodynia (Figure; P=0.21)
- The PCA3 Score was less than 30 in all patients, less than 20 in 88% of patients and less than 10 in 65% of patients
- Men with abacterial chronic prostatitis had significantly more prostate cells in the urine sample compared to men with other types of chronic prostatitis. The number of PSA RNA transcripts was significantly increased, as was the number of PCA3 RNA transcripts, resulting in a median PCA3 Score that was similar to that in men with other types of chronic prostatitis
- The informative rate of the PCA3 test was 100%. This shows that the PCA3 test is robust and can be included within the Meares-Stamey localization test in men with suspicion for chronic prostatitis or prostate cancer
- It was concluded that the PCA3 Score is not affected by chronic prostatitis. The PCA3 Score was low and comparable in men with bacterial chronic prostatitis, abacterial chronic prostatitis and prostatodynia. The PCA3 test is a valuable tool in patients with elevated PSA levels and suspicion of chronic prostatitis to distinguish those patients who will really benefit from prostate biopsy from those in whom a biopsy can be avoided
Figure. The mean and median PCA3 Scores are low and comparable in men with bacterial chronic prostatitis, abacterial chronic prostatitis and prostatodynia
More information: Article at PubMed